328 W. Claiborne St.
P.O. Box 964
Monroeville, Alabama 36460
(251) 575-4203
     
Aging & Geriatrics
Resources
Basic InformationLatest News
How Well Are You Aging? A Blood Test Might TellTaking Several Prescription Drugs May Trigger Serious Side EffectsAir Pollution May Up Glaucoma RiskEven in Small Doses, Air Pollution Harms Older AmericansCan Air Pollution Take a Toll on Your Memory?AHA News: Obesity, Other Factors May Speed Up Brain AgingMuscle in Middle Age Might Help Men's Hearts LaterFish Oil Rx Slows Clogging in ArteriesAlmost Half of Older Americans Fear Dementia, Try Untested Ways to Fight ItPeople Who Can't Read Face 2-3 Times Higher Dementia RiskAHA News: Omega-3 May Boost Brain Health in People With a Common Heart DiseaseCommon Muscle Relaxant Could Pose Mental Dangers for SeniorsEducation a Buffer Against Alzheimer's Among Blacks: StudyEven a Little Exercise May Bring a Brain BoostVitamin D is Key to Muscle Strength in Older AdultsMany Older Americans Misuse Antibiotics: PollMany on Medicare Still Face Crippling Medical BillsNumber of Americans With Dementia Will Double by 2040: Report'Dramatic Increase' Seen in U.S. Deaths From Heart FailureToo Many Seniors Back in Hospital for Infections Treated During First StayFor Seniors, Financial Woes Can Be Forerunner to Alzheimer'sGet Moving: Exercise Can Help Lower Older Women's Fracture RiskDon't Forget These Tips to Boost Your MemoryFamily Can Help Keep Delirium at Bay After SurgeryHow to Manage Your OsteoarthritisHealth Tip: Brain Games for SeniorsYour Personality as a Teen May Predict Your Risk of DementiaSteroid Shots for Painful Joints May Make Matters WorseHow Fast You Walk Might Show How Fast You're AgingStandard Memory Tests for Seniors Might Differ by GenderAHA News: Growing – and Aging – Hispanic Population at Risk for DementiaStroke Rate Continues to Fall Among Older AmericansMany U.S. Seniors Are Going Hungry, Study FindsMany Poor, Minority Seniors Get Cancer Diagnosis in the ERGive Seniors a Memory Check at Annual Checkups, Experts SayFor People at High Risk, Evidence That Exercise Might Slow Alzheimer'sStaying Healthy Now to Work Into Older AgeAggressive Blood Pressure Treatment Does Not Put Seniors at Risk: StudyCan Older Women Stop Getting Mammograms?Getting Hitched Might Lower Your Odds for DementiaMany Older Americans Aren't Equipped to Weather Hurricanes Like DorianHow You Can Help Head Off Alzheimer's DiseaseWho's Most Likely to Scam a Senior? The Answer May Surprise YouAHA News: Time With Grandkids Could Boost Health – Even LifespanAHA News: It's Never Too Late to Reap Health Rewards of Exercise, Strength TrainingIs Your Forgetfulness Reason for Concern?For Seniors, 'Silent Strokes' Are Common Post-Surgery Threat: StudyDodge Dementia With Healthy LifestyleWhen Is It Time for Seniors to Hand Over the Car Keys?Supplement Pills Can Pose Choking Risk for Seniors, Study Finds
LinksSelf-Help Groups
Related Topics

Depression: Depression & Related Conditions
Elder Care

Too Much Napping May Signal Alzheimer's

HealthDay News
by -- Robert Preidt
Updated: Aug 12th 2019

new article illustration

MONDAY, Aug. 12, 2019 (HealthDay News) -- If you often find yourself dosing off during the day, new research suggests it might be an early warning sign that you have Alzheimer's disease.

Areas of the brain that keep you awake during the day are damaged in the early stages of the memory-robbing disease, which is why people with Alzheimer's may nap excessively long before they start to struggle with forgetting things, the study authors said.

Not only that, the scientists also found that damage to brain regions involved in daytime wakefulness was caused by a protein called tau. This provides more evidence that tau may play a larger role in Alzheimer's than the more extensively studied amyloid protein, the researchers noted.

"Our work shows definitive evidence that the brain areas promoting wakefulness degenerate due to accumulation of tau -- not amyloid protein -- from the very earliest stages of the disease," said study senior author Dr. Lea Grinberg. She is an associate professor of neurology and pathology at the Memory and Aging Center and a member of the Global Brain Health Institute at the University of California, San Francisco (UCSF).

Previous research has suggested that excessive napping is due to poor sleep caused by Alzheimer's-related disruptions in brain regions that promote sleep, or that sleep problems themselves contribute to Alzheimer's disease progression.

In this study, the researchers analyzed the brains of 13 deceased Alzheimer's patients and seven people without the disease. The investigators concluded that Alzheimer's disease attacks brain regions responsible for wakefulness during the day, and that these regions are among the first damaged by the disease.

The findings suggest that excessive daytime napping could serve as an early harbinger of Alzheimer's.

In the Alzheimer's-affected brains, significant tau buildup was found in all three wakefulness-promoting centers examined by the researchers, and those regions had lost as many as 75% of their neurons.

The findings were published Aug. 12 in the journal Alzheimer's and Dementia.

According to study lead author Jun Oh, a Grinberg lab research associate, "It's remarkable because it's not just a single brain nucleus that's degenerating, but the whole wakefulness-promoting network. Crucially, this means that the brain has no way to compensate because all of these functionally related cell types are being destroyed at the same time," Oh explained.

"It seems that the wakefulness-promoting network is particularly vulnerable in Alzheimer's disease," Oh said in a UCSF news release. "Understanding why this is the case is something we need to follow up in future research."

This and other findings suggest that tau buildup plays a greater role in Alzheimer's than the more widely studied amyloid protein. Research into amyloid has so far failed to result in effective Alzheimer's treatments, according to the UCSF team.

Grinberg said that the "research adds to a growing body of work showing that tau burden is likely a direct driver of [mental] decline."

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.




328 W. Claiborne St.
P.O. Box 964
Monroeville,
Alabama 36460
Tel: (251)575-4203
Fax:(251)575-9459


powered by centersite dot net