328 W. Claiborne St.
P.O. Box 964
Monroeville, Alabama 36460
(251) 575-4203
     
Bipolar Disorder
Resources
Basic Information
Introduction to Bipolar DisorderCurrent Understandings of the Causes of Bipolar DisorderDiagnosis of Bipolar DisorderMedication Treatments for Bipolar DisorderPsychotherapy and Other TreatmentsSelf-Help and Helping OthersReferences and Reading List
More InformationTestsLatest NewsLinks
Related Topics

Depression: Depression & Related Conditions
Suicide
Addictions: Alcohol and Substance Abuse

Simple ECG May Help Distinguish MDD From Bipolar Depression


HealthDay News
Updated: Nov 28th 2017

new article illustration

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Heart rate variability (HRV) and specific inflammatory biomarkers can differentiate major depressive disorder (MDD) from depression in bipolar disorder (BD), according to a study published online Oct. 5 in The World Journal of Biological Psychiatry.

Brandon Hage, M.D., from the Loyola University Chicago Stritch School of Medicine in Maywood, Ill., and colleagues quantified HRV and measured inflammatory biomarkers in 64 patients with MDD and 37 with BD.

The researchers found that, compared with BD subjects, MDD subjects had significantly higher baseline respiratory sinus arrhythmia (P = 0.05) and low-frequency (LF)-HRV (P < 0.01). BD subjects had significantly higher baseline levels of interleukin-10 (IL-10; P < 0.01) and monocyte chemoattractant protein-1 (P < 0.01) than MDD subjects. Baseline LF-HRV was significantly positively associated with baseline levels of IL-10 in the MDD group only (r = 0.47; P < 0.01).

"Reduced vagal tone and higher levels of inflammatory biomarkers may distinguish BD from MDD and reveal an underlying pathophysiology of depression involving autonomic nervous system dysfunction and chronic immune system dysregulation," the authors write.

Abstract/Full Text (subscription or payment may be required)




328 W. Claiborne St.
P.O. Box 964
Monroeville,
Alabama 36460
Tel: (251)575-4203
Fax:(251)575-9459


powered by centersite dot net